Motif ID: STAT5{A,B}.p2

Z-value: 0.766


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
STAT5Bhg19_v1_chr17_-_40428311_40428390-0.722.9e-02Click!
STAT5Ahg19_v1_chr17_+_40439564_40439564-0.265.0e-01Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_44617510 2.743 NM_013362
 ZNF225
zinc finger protein 225
chr19_+_44507076 1.938 NM_006300
 ZNF230
zinc finger protein 230
chr19_+_44576266 1.431 NM_001037813
 ZNF284
zinc finger protein 284
chr15_+_90895476 1.400 NM_001004309
 ZNF774
zinc finger protein 774
chr19_+_44645728 1.249 ZNF234
zinc finger protein 234
chr19_-_44617271 1.104 LOC100379224
uncharacterized LOC100379224
chr19_-_44439410 1.090 NM_003425
 ZNF45
zinc finger protein 45
chr19_-_44860798 1.041 NM_001083335
NM_013380
 ZFP112

zinc finger protein 112 homolog (mouse)

chr19_+_40502942 1.030 NM_178544
 ZNF546
zinc finger protein 546
chr5_+_140474198 0.995 NM_018936
 PCDHB2
protocadherin beta 2
chr19_+_44556163 0.980 NM_013361
 ZNF223
zinc finger protein 223
chr19_+_44645708 0.977 NM_001144824
NM_006630
 ZNF234

zinc finger protein 234

chr3_+_180319898 0.927 NM_001042601
NM_133462
 TTC14

tetratricopeptide repeat domain 14

chr19_+_35168558 0.822 NM_001012320
NM_018443
 ZNF302

zinc finger protein 302

chr19_+_44529493 0.802 NM_001129996
NM_013360
 ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr19_-_45004482 0.769 NM_013256
 ZNF180
zinc finger protein 180
chr19_-_58326280 0.761 NM_024762
 ZNF552
zinc finger protein 552
chr19_-_40596781 0.730 NM_001010880
NM_001142577
NM_001142578
NM_001142579
 ZNF780A



zinc finger protein 780A



chr19_-_44809126 0.659 NM_004234
 ZNF235
zinc finger protein 235
chr19_+_37341724 0.617 NM_001242472
NM_001242474
 ZNF345

zinc finger protein 345

chr1_-_155112720 0.606 NM_018973
NM_153741
 DPM3

dolichyl-phosphate mannosyltransferase polypeptide 3

chr8_+_27631902 0.568 NM_001017420
 ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr2_-_231084600 0.560 NM_004509
NM_004510
NM_080424
 SP110


SP110 nuclear body protein


chr19_-_57988891 0.555 NM_001024596
NM_001144068
 ZNF772

zinc finger protein 772

chr5_-_111093251 0.554 NM_001142479
NM_001142480
NM_001142478
 C5orf13


chromosome 5 open reading frame 13


chr1_+_40942878 0.554 ZNF642
zinc finger protein 642
chr9_-_115774471 0.542 NM_001101338
 ZNF883
zinc finger protein 883
chr20_-_18477811 0.530 NM_006606
 RBBP9
retinoblastoma binding protein 9
chr19_+_44455379 0.517 NM_013359
 ZNF221
zinc finger protein 221
chr1_+_54519259 0.512 NM_153035
 TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr19_+_44598479 0.507 NM_013398
 ZNF224
zinc finger protein 224
chr20_+_34556528 0.494 NM_001207076
NM_080834
 C20orf152

chromosome 20 open reading frame 152

chr6_-_27440459 0.493 NM_007149
 ZNF184
zinc finger protein 184
chr19_+_58341661 0.482 NM_001204818
 LOC100293516
zinc finger protein
chr3_+_58484091 0.480 NM_153331
 KCTD6
potassium channel tetramerisation domain containing 6
chr19_+_45909868 0.473 CD3EAP
CD3e molecule, epsilon associated protein
chr5_+_178450775 0.462 NM_001136116
 ZNF879
zinc finger protein 879
chr3_-_14166370 0.450 NM_001098502
NM_144636
 CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

chr5_+_32585604 0.446 NM_006713
 SUB1
SUB1 homolog (S. cerevisiae)
chr7_-_134001502 0.437 SLC35B4
solute carrier family 35, member B4
chr16_-_53737713 0.432 NM_001127897
NM_015272
 RPGRIP1L

RPGRIP1-like

chr4_+_156824846 0.430 NM_005651
 TDO2
tryptophan 2,3-dioxygenase
chr19_+_37341259 0.424 NM_003419
 ZNF345
zinc finger protein 345
chr1_+_153631144 0.420 NM_012437
 SNAPIN
SNAP-associated protein
chr3_-_14166292 0.416 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr7_-_134001749 0.411 NM_032826
 SLC35B4
solute carrier family 35, member B4
chr19_-_58427934 0.409 NM_152475
 ZNF417
zinc finger protein 417
chr19_+_58331067 0.399 LOC100293516
zinc finger protein
chr9_-_34376831 0.394 NM_020702
 KIAA1161
KIAA1161
chr1_+_153631193 0.393 SNAPIN
SNAP-associated protein
chr14_+_97263681 0.383 NM_003384
 VRK1
vaccinia related kinase 1
chr3_-_14166246 0.382 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr5_+_137514753 0.381 KIF20A
kinesin family member 20A
chr7_-_150754934 0.380 CDK5
cyclin-dependent kinase 5
chr19_+_35225095 0.371 ZNF181
zinc finger protein 181
chr11_-_125773086 0.361 NM_031307
 PUS3
pseudouridylate synthase 3
chr3_-_14166228 0.357 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr6_+_139094656 0.356 NM_015439
 CCDC28A
coiled-coil domain containing 28A
chr19_-_58220535 0.354 NM_001085384
 ZNF154
zinc finger protein 154
chr14_-_82000112 0.344 SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr6_-_139094788 0.343 NM_001242740
 LOC100507462
uncharacterized LOC100507462
chr10_-_98325100 0.337 TM9SF3
transmembrane 9 superfamily member 3
chr4_+_86396251 0.331 NM_001025616
 ARHGAP24
Rho GTPase activating protein 24
chr1_+_3773844 0.330 NM_004402
 DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
chr1_-_33502428 0.330 AK2
adenylate kinase 2
chr1_-_33502452 0.321 AK2
adenylate kinase 2
chr4_+_84457256 0.320 AGPAT9
1-acylglycerol-3-phosphate O-acyltransferase 9
chr12_-_133532847 0.318 NM_183238
NM_001164715
 ZNF605

zinc finger protein 605

chr1_-_33502484 0.317 NM_001199199
NM_001625
NM_013411
 AK2


adenylate kinase 2


chr5_+_137514416 0.317 NM_005733
 KIF20A
kinesin family member 20A
chr7_+_142985307 0.312 NM_032982
NM_032983
 CASP2

caspase 2, apoptosis-related cysteine peptidase

chr1_+_40997290 0.308 ZNF684
zinc finger protein 684
chr19_+_44669214 0.304 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
 ZNF226




zinc finger protein 226




chrX_+_107288199 0.303 NM_001170553
NM_182607
 VSIG1

V-set and immunoglobulin domain containing 1

chr18_+_43684297 0.291 NM_138443
 HAUS1
HAUS augmin-like complex, subunit 1
chr19_-_44405934 0.290 LOC100505715
uncharacterized LOC100505715
chr5_-_102898450 0.290 NM_031438
 NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
chr1_-_33502464 0.273 AK2
adenylate kinase 2
chr12_-_46384208 0.268 SCAF11
SR-related CTD-associated factor 11
chr19_-_35264091 0.267 NM_001007248
 ZNF599
zinc finger protein 599
chr17_-_7142597 0.265 NM_024297
 PHF23
PHD finger protein 23
chr22_+_39077975 0.262 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr19_+_57946662 0.258 NM_001023561
 ZNF749
zinc finger protein 749
chr17_+_15603046 0.254 ZNF286A
zinc finger protein 286A
chr14_-_82000198 0.252 NM_001244984
NM_005065
 SEL1L

sel-1 suppressor of lin-12-like (C. elegans)

chr10_-_121355978 0.251 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr19_+_35225124 0.251 ZNF181
zinc finger protein 181
chr1_+_40997232 0.251 NM_152373
 ZNF684
zinc finger protein 684
chr19_+_58920118 0.249 ZNF584
zinc finger protein 584
chr22_+_39077960 0.246 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr16_-_70472920 0.243 NM_006927
 ST3GAL2
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr20_+_12989616 0.238 NM_018327
 SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr19_+_58920007 0.237 NM_173548
 ZNF584
zinc finger protein 584
chr11_+_134123406 0.236 NM_014384
 ACAD8
acyl-CoA dehydrogenase family, member 8
chr19_-_58514136 0.235 ZNF606
zinc finger protein 606
chr13_+_115079943 0.234 NM_001164144
NM_001164145
NM_032436
 CHAMP1


chromosome alignment maintaining phosphoprotein 1


chr1_-_212588239 0.232 NM_001198862
NM_018252
 TMEM206

transmembrane protein 206

chr11_-_134123138 0.229 NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298
 THYN1




thymocyte nuclear protein 1




chr7_+_5862768 0.227 ZNF815
zinc finger protein 815
chr1_-_212588235 0.225 TMEM206
transmembrane protein 206
chr2_+_95831176 0.220 NM_001017396
NM_021088
 ZNF2

zinc finger protein 2

chr22_-_38902281 0.219 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr7_-_107443631 0.219 NM_000111
 SLC26A3
solute carrier family 26, member 3
chr20_-_48530275 0.219 NM_001135773
 SPATA2
spermatogenesis associated 2
chr1_-_33502470 0.218 AK2
adenylate kinase 2
chr19_+_58144510 0.217 NM_006385
NM_198855
 ZNF211

zinc finger protein 211

chr19_+_37709068 0.215 ZNF383
zinc finger protein 383
chr19_+_37407230 0.215 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
 ZNF568





zinc finger protein 568





chr14_-_70883680 0.212 NM_001202547
NM_001202548
NM_001202549
NM_018373
 SYNJ2BP-COX16


SYNJ2BP
SYNJ2BP-COX16 readthrough


synaptojanin 2 binding protein
chr1_+_179051111 0.212 NM_022371
 TOR3A
torsin family 3, member A
chr12_-_63546589 0.211 NM_000706
 AVPR1A
arginine vasopressin receptor 1A
chr2_-_142888540 0.209 LRP1B
low density lipoprotein receptor-related protein 1B
chr9_-_99616385 0.209 NM_001001662
 ZNF782
zinc finger protein 782
chr2_+_63816143 0.207 NM_001199111
NM_001199112
 MDH1

malate dehydrogenase 1, NAD (soluble)

chr1_+_179051233 0.205 TOR3A
torsin family 3, member A
chr2_+_95831533 0.201 ZNF2
zinc finger protein 2
chr11_-_72504643 0.199 NM_006645
 STARD10
StAR-related lipid transfer (START) domain containing 10
chr7_+_142960588 0.199 GSTK1
glutathione S-transferase kappa 1
chr22_+_39077953 0.199 NM_020243
 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr19_+_44331443 0.198 NM_181845
 ZNF283
zinc finger protein 283
chr19_-_44952630 0.195 NM_014518
 ZNF229
zinc finger protein 229
chr6_-_116601085 0.193 TSPYL1
TSPY-like 1
chr3_+_122399665 0.193 NM_017554
 PARP14
poly (ADP-ribose) polymerase family, member 14
chr22_-_38902315 0.188 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr4_-_76957139 0.188 NM_005409
 CXCL11
chemokine (C-X-C motif) ligand 11
chrX_+_106045880 0.187 NM_017752
NM_198881
 TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr2_-_172290435 0.186 METTL8
methyltransferase like 8
chr8_-_33330630 0.182 NM_032664
 FUT10
fucosyltransferase 10 (alpha (1,3) fucosyltransferase)
chr9_+_104161118 0.180 NM_003452
NM_197977
 ZNF189

zinc finger protein 189

chrX_-_154563735 0.178 NM_001289
 CLIC2
chloride intracellular channel 2
chr11_+_82783118 0.177 LOC100506233
uncharacterized LOC100506233
chr16_-_56485113 0.177 NM_007006
 NUDT21
nudix (nucleoside diphosphate linked moiety X)-type motif 21
chr1_-_202927269 0.177 ADIPOR1
adiponectin receptor 1
chr19_+_58361219 0.174 ZNF587
zinc finger protein 587
chr1_+_179051218 0.173 TOR3A
torsin family 3, member A
chr5_+_140753480 0.172 NM_018919
NM_032086
 PCDHGA6

protocadherin gamma subfamily A, 6

chr22_+_39077979 0.169 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chrX_+_149737019 0.169 NM_000252
 MTM1
myotubularin 1
chr16_+_53468373 0.167 RBL2
retinoblastoma-like 2 (p130)
chr22_-_38902344 0.167 NM_001098504
NM_006386
 DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr16_+_53468344 0.167 NM_005611
 RBL2
retinoblastoma-like 2 (p130)
chr7_+_26400503 0.163 NM_001199837
 SNX10
sorting nexin 10
chr1_-_153521717 0.162 NM_002960
 S100A3
S100 calcium binding protein A3
chr19_-_49250023 0.160 NM_182575
 IZUMO1
izumo sperm-egg fusion 1
chrX_-_139866582 0.160 NM_004065
 CDR1
cerebellar degeneration-related protein 1, 34kDa
chr5_-_95158365 0.158 GLRX
glutaredoxin (thioltransferase)
chr17_-_48945338 0.157 NM_001243877
 TOB1
transducer of ERBB2, 1
chr15_+_48624354 0.154 NM_001948
 DUT
deoxyuridine triphosphatase
chr19_-_37341168 0.154 NM_001242801
 ZNF790
zinc finger protein 790
chr9_-_104160876 0.154 NM_019051
 MRPL50
mitochondrial ribosomal protein L50
chr12_+_80603232 0.152 NM_173591
 OTOGL
otogelin-like
chr1_+_53392957 0.151 SCP2
sterol carrier protein 2
chr19_-_37263653 0.150 NM_001193552
 ZNF850
zinc finger protein 850
chr16_+_53468406 0.148 RBL2
retinoblastoma-like 2 (p130)
chr7_-_150754979 0.147 NM_001164410
NM_004935
 CDK5

cyclin-dependent kinase 5

chr16_+_53468390 0.143 RBL2
retinoblastoma-like 2 (p130)
chr6_+_116601282 0.143 NM_001080976
 DSE
dermatan sulfate epimerase
chr2_+_150187028 0.142 NM_194317
 LYPD6
LY6/PLAUR domain containing 6
chr1_-_184724021 0.141 NM_025191
 EDEM3
ER degradation enhancer, mannosidase alpha-like 3
chr22_-_38902300 0.138 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr7_+_99102572 0.138 NM_014569
 ZKSCAN5
zinc finger with KRAB and SCAN domains 5
chr11_+_72980938 0.137 NM_176798
 P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr16_-_67260720 0.137 NM_012163
 LRRC29
leucine rich repeat containing 29
chr1_-_212588073 0.133 TMEM206
transmembrane protein 206
chr5_+_175665337 0.133 NM_198567
 C5orf25
chromosome 5 open reading frame 25
chrX_+_149737083 0.132 MTM1
myotubularin 1
chr19_+_17416476 0.132 NM_023937
 MRPL34
mitochondrial ribosomal protein L34
chr6_+_99968851 0.130 NM_001195131
 LOC100130890
uncharacterized LOC100130890
chr12_-_46384346 0.124 SCAF11
SR-related CTD-associated factor 11
chr18_-_53071225 0.124 NM_001243232
 TCF4
transcription factor 4
chr19_-_37019169 0.123 NM_001012756
NM_001166036
NM_001166037
NM_001166038
 ZNF260



zinc finger protein 260



chr7_+_87563432 0.122 NM_004194
NM_016351
NM_021721
NM_021722
NM_021723
 ADAM22




ADAM metallopeptidase domain 22




chr2_+_88991166 0.121 NM_144563
 RPIA
ribose 5-phosphate isomerase A
chr16_+_53468362 0.121 RBL2
retinoblastoma-like 2 (p130)
chr3_-_52188398 0.119 POC1A
POC1 centriolar protein homolog A (Chlamydomonas)
chr1_+_53392900 0.119 NM_001007098
NM_001193599
NM_001193600
NM_001193617
NM_002979
 SCP2




sterol carrier protein 2




chr6_-_83903632 0.119 NM_001199917
 PGM3
phosphoglucomutase 3
chr15_+_74753602 0.118 LOC440288
uncharacterized LOC440288
chr19_+_35225479 0.114 NM_001029997
NM_001145665
 ZNF181

zinc finger protein 181

chr7_+_99717260 0.114 NM_152755
 CNPY4
canopy 4 homolog (zebrafish)
chr11_+_73357222 0.113 NM_001130033
NM_021200
 PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr3_-_119379269 0.112 NM_022135
 POPDC2
popeye domain containing 2
chr6_-_116600283 0.112 TSPYL1
TSPY-like 1
chr12_+_102271082 0.111 NM_018370
 DRAM1
DNA-damage regulated autophagy modulator 1
chr3_+_169940246 0.109 PRKCI
protein kinase C, iota
chr21_+_27107731 0.107 GABPA
GA binding protein transcription factor, alpha subunit 60kDa
chr22_+_22020272 0.107 NM_014337
NM_148175
NM_148176
 PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr1_+_91966365 0.106 NM_001134419
NM_003503
 CDC7

cell division cycle 7 homolog (S. cerevisiae)

chr12_-_10324675 0.106 NM_001172632
NM_001172633
NM_002543
 OLR1


oxidized low density lipoprotein (lectin-like) receptor 1


chr4_+_25378816 0.104 NM_013367
 ANAPC4
anaphase promoting complex subunit 4
chr1_+_244217283 0.101


chr17_-_18266691 0.101 NM_004169
NM_148918
 SHMT1

serine hydroxymethyltransferase 1 (soluble)

chr14_-_68162419 0.100 NM_001252650
NM_016026
 RDH11

retinol dehydrogenase 11 (all-trans/9-cis/11-cis)

chr10_-_33623299 0.100 NRP1
neuropilin 1
chr11_-_82996898 0.099 CCDC90B
coiled-coil domain containing 90B
chr19_-_37406918 0.096 NM_001171979
 ZNF829
zinc finger protein 829
chr8_+_27950583 0.096 NM_018091
 ELP3
elongation protein 3 homolog (S. cerevisiae)
chr17_+_80317122 0.094 NM_207459
 TEX19
testis expressed 19
chr10_-_38265452 0.092 NM_145011
 ZNF25
zinc finger protein 25
chr6_-_116601102 0.092 NM_003309
 TSPYL1
TSPY-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.31 1.86e-03 GO:0006355 regulation of transcription, DNA-dependent
6.08 2.24e-03 GO:0051252 regulation of RNA metabolic process
5.70 3.09e-03 GO:2000112 regulation of cellular macromolecule biosynthetic process
5.56 3.51e-03 GO:0010556 regulation of macromolecule biosynthetic process
5.40 4.06e-03 GO:0010468 regulation of gene expression
5.18 5.02e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
5.18 5.02e-03 GO:0031326 regulation of cellular biosynthetic process
5.12 5.30e-03 GO:0009889 regulation of biosynthetic process
5.03 5.81e-03 GO:0051171 regulation of nitrogen compound metabolic process
4.15 1.52e-02 GO:0060255 regulation of macromolecule metabolic process
3.94 1.96e-02 GO:0080090 regulation of primary metabolic process
3.89 2.09e-02 GO:0031323 regulation of cellular metabolic process
3.55 3.33e-02 GO:0019222 regulation of metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
7.69 1.78e-05 GO:0008270 zinc ion binding
6.79 3.82e-05 GO:0003677 DNA binding
6.78 3.86e-05 GO:0046914 transition metal ion binding
4.82 3.16e-04 GO:0003676 nucleic acid binding
4.08 8.80e-04 GO:0046872 metal ion binding
4.04 9.41e-04 GO:0043169 cation binding
4.03 9.55e-04 GO:0043167 ion binding